Journal article
Cerebral Oxygenation during Neonatal Intubation with Nasal High Flow: A Sub-Study of the SHINE Randomized Trial
E Van Der Veeken, BJ Manley, L Owen, O Kamlin, C Roberts, S Newman, K Francis, S Donath, P Davis, R Cuzzilla, KA Hodgson
Neonatology | Published : 2023
DOI: 10.1159/000529870
Abstract
Introduction: Nasal high flow (nHF) improves the likelihood of successful neonatal intubation on the first attempt without physiological instability. The effect of nHF on cerebral oxygenation is unknown. The aim of this study was to compare cerebral oxygenation during endotracheal intubation in neonates receiving nHF and those receiving standard care. Methods: A sub-study of a multicentre randomized trial of nHF during neonatal endotracheal intubation. A subset of infants had near-infrared spectroscopy (NIRS) monitoring. Eligible infants were randomly assigned to nHF or standard care during the first intubation attempt. NIRS sensors provided continuous regional cerebral oxygen saturation (rS..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (Grant No. 1098790). Vapotherm (Exeter, NH, USA) and Nonin (Plymouth, MN, USA) provided equipment for the trial but had no input into trial design, data accrual, data analysis, or manuscript preparation, and no access to the trial data.